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// Family Practice and Internal Medicine // 09.15.2008
Childhood Cancer Gene Discovered
Recent research conducted by The Children's Hospital of Philadelphia has uncovered the gene mutations responsible for the inherited version of the childhood cancer neuroblastoma. These mutations also play a key role in high-risk forms of the more common childhood cancer, non-inherited neuroblastoma.
While it first appears as a tumor in the abdomen or chest, neuroblastoma actually begins to form in a child's developing nerves. The most common cancer in infancy, neuroblastoma only accounts for six to ten percent of all childhood cancers. However, because it is an aggressive cancer, the disease is responsible for fifteen percent of all cancer deaths in children.
This important discovery will enable physicians to provide simple, non-invasive genetic screening to families affected by inherited neuroblastoma in the hope of early detection. In addition, the discovery is generating ideas for curative therapies; various pharmaceutical companies are already at work developing cancer-inhibiting drugs.
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